There can be more to multiple sclerosis (MS) than the readily apparent symptoms (see figure). Regularly monitoring disease activity can give early warning that MS is not responding well to treatment. Underlying signs of MS disease activity may be seen using magnetic resonance imaging (MRI). Healthcare professionals should monitor all disease activity that predicts relapses and disability progression. MRI or clinical evidence that disease activity is poorly controlled should prompt discussion about the possibility of switching to a disease-modifying therapy (DMT) that acts on the body in a different way.
The articles in this section discuss the latest evidence for regular monitoring of disease activity.