Long-term management

Ongoing disease activity damages tissue in the brain and spinal cord even if it doesn’t immediately lead to a relapse. Regularly monitoring disease activity using magnetic resonance imaging (MRI) can give early warning if MS is not responding well to treatment. Evidence that disease activity is poorly controlled should prompt discussion about the possibility of switching to a disease-modifying therapy (DMT) that acts on the body in a different way.

The articles in this section discuss the latest evidence for regular monitoring of disease activity and switching DMTs.